Latest review on Extracellular vesicles for Cardiovascular Therapeutics in Nature Reviews Cardiology

We are delighted to share the latest review ‘Native and bioengineered extracellular vesicles for cardiovascular therapeutics’ published in Nature Reviews Cardiology from our EU-CardioRNA colleagues.

Access the article here!

Key points

  • Extracellular vesicles (EVs) secreted from stem or progenitor cells and from differentiated somatic cells have regenerative properties in the context of myocardial infarction, ischaemic limb disease and stroke.
  • Despite the benefits of native EVs as delivery agents, their application in the cardiovascular context is hindered by intrinsic drawbacks, such as their undefined and heterogeneous nature and limited tropism.
  • EVs can be improved by bioengineering approaches using both pre-isolation and post-isolation methods to increase the targeting, bioactivity, kinetics, biodistribution and contents of EVs.
  • Bioengineering of EVs is necessary to improve their clinical potential for cardiovascular applications.